Smart Money Abandons Single-Asset Risk: Why Platforms Now Command 60% of Pharma Pipelines

PR Newswire

VANCOUVER, BC, Dec. 19, 2025

Issued on behalf of GT Biopharma, Inc.

(NADSAQ: TCRX).GT Biopharma, Inc.ADC Therapeutics SA Sutro Biopharma, Inc.Crinetics Pharmaceuticals, Inc.TScan Therapeutics, Inc.Equity InsiderNews CommentaryVANCOUVER, BCDec. 19, 2025^[1]^[2]

Platform technologies now account for 60% of total pharma pipeline value, with immunotherapies commanding over 45% of cancer drug revenues as investors reward modularity over one-shot bets^[1]^[3]

advancing its Phase 1 clinical trial of GTB-3650 to Cohort 4, where patients now receive 10μg/kg/day dosing. The company specializes in developing next-generation immunotherapy treatments targeting some of the world's most resistant cancer types through its proprietary natural killer cell engager TriKE platform.recently reportedGT Biopharma, Inc.

Phase 1 dose escalation trial evaluates GTB-3650 in patients facing relapsed or refractory blood cancers expressing CD33, particularly acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS). These cancers represent exceptionally challenging cases where conventional treatments have either failed completely or provided only temporary benefit before disease returned.GT Biopharma's

The therapy harnesses the patient's natural killer cells, an immune cell type that instinctively identifies and eliminates abnormal cells, directing them to attack cancer specifically. Treatment delivery follows a continuous infusion schedule structured as two-week treatment periods followed by two-week rest intervals, with cycles continuing up to four months depending on individual patient response.

"We are highly encouraged by the continued progress of our Phase 1 clinical trial evaluating GTB-3650 in cancer patients, which has now advanced to Cohort 4 at a dose level of 10 µg/kg/day," said Michael Breen, Executive Chairman and CEO. "We look forward to assessing higher doses, as we are now approaching the efficacy range predicted by preclinical in vivo leukemia models, and we plan to share the next trial update in the first quarter of 2026."

Thesix patients enrolledGT Biopharma

The first-in-human Phase 1 protocol plans for approximately 14 patients distributed across seven cohorts, with each cohort enrolling two patients at progressively increasing doses starting from 1.25μg/kg/day in Cohort 1 and potentially reaching 100μg/kg/day in Cohort 7 if warranted. Following Cohort 4, three additional escalation levels remain: Cohort 5 testing 25μg/kg/day, Cohort 6 evaluating 50μg/kg/day, and Cohort 7 examining the maximum protocol dose of 100μg/kg/day. The company anticipates providing its next comprehensive trial update during first quarter 2026.

Beyond hematologic malignancies,GT Biopharma

Designed as a subcutaneous injection, GTB-5550 offers the potential for eventual self-administration at home, significantly reducing patient burden.

Both therapeutic candidates leverageGT Biopharma'sGT BiopharmaUniversity of Minnesota

https://equity-insider.com/2025/10/03/the-small-biotech-thats-cracking-the-code-big-pharma-paid-billions-for/CONTINUED… Read this and more news for GT Biopharma, Inc. at:

from its LOTIS-7 Phase 1b trial showing ZYNLONTA in combination with glofitamab achieved an 89.8% overall response rate and 77.6% complete response rate across 49 efficacy-evaluable patients with relapsed/refractory diffuse large B-cell lymphoma. The combination demonstrated strong efficacy in both relapsed (100% ORR, 91.7% CR) and primary refractory populations (80% ORR, 64% CR) while maintaining a manageable safety profile with cytokine release syndrome occurring in 36.7% of patients across dose levels.updated dataADC Therapeutics SA

"We're excited that these data continue to demonstrate a manageable safety profile and strong efficacy including deep and durable responses in 2L+ r/r DLBCL patients treated with ZYNLONTA plus glofitamab," said Mohamed Zaki, MD, PhD, CMO ofADC Therapeutics

expects to complete enrollment of approximately 100 patients at the selected 150 µg/kg dose during the first half of 2026. The company plans to share full data at a medical meeting and submit for publication by the end of 2026 while assessing regulatory and compendia strategies for this potential best-in-class bispecific antibody-based combination.ADC Therapeutics

of patients in its Phase 1 trial evaluating STRO-004, a next-generation Tissue Factor-targeting exatecan antibody-drug conjugate designed for enhanced stability, potency, and tumor selectivity. The multicenter trial is assessing safety, pharmacokinetics, and preliminary anti-tumor activity in patients with TF-expressing solid tumors including non-small cell lung cancer, head and neck squamous cell carcinoma, cervical cancer, colorectal cancer, pancreatic ductal adenocarcinoma, and bladder cancer.dosed the first cohortSutro Biopharma, Inc.

"Dosing the initial patients in this trial marks an important milestone in bringing forward new treatment options for patients with TF–expressing cancers—many of whom face limited therapy options and difficult prognoses," said Jane Chung, CEO ofSutro Biopharma

The dose-escalation phase features high entry doses supported by strong tolerability in non-human primates at up to 50 mg/kg, with initial clinical data expected in mid-2026.Sutro's

proprietary NDC platform, designed to bind selectively to SST2-expressing tumor cells while promoting rapid receptor internalization to release a cytotoxic payload directly within tumors.dosed the first patientCrinetics Pharmaceuticals, Inc.Crinetics'

"We developed CRN09682 to address the need for a more efficacious, safer, and convenient targeted therapy for patients with SST2-expressing tumors," said Stephen Betz, Ph.D., Chief Scientific Officer and Co-Founder ofCrinetics

The first-in-human, open-label trial will enroll up to 150 participants with dose escalation followed by expansion phases evaluating safety, tolerability, pharmacokinetics and preliminary anti-tumor activity. CRN09682 utilizes traditional chemical synthesis methods, eliminating manufacturing constraints required by most antibody drug conjugates and radiopharmaceuticals.

from its ALLOHA Phase 1 trial showing TSC-101 continued to demonstrate favorable relapse-free survival (HR=0.50) and overall survival (HR=0.61) in patients with hematologic malignancies undergoing allogeneic hematopoietic cell transplantation. All three TSC-101-treated patients who reached two-year follow-up remained relapse-free compared to only one of four patients (25%) in the control arm, with no dose-limiting toxicities observed across all dose levels.positive updated dataTScan Therapeutics, Inc.

"These updated data from our Phase 1 study continue to highlight a positive safety and efficacy profile of TSC-101 in patients with heme malignancies undergoing allogeneic HCT," said Chrystal U. Louis, MD, CMO ofTScan Therapeutics

is focused on enrolling the remaining patients necessary to support its fixed-dosing regimen and expects to initiate a pivotal study in the second quarter of 2026. The company plans to expand its heme program in 2026 with product candidates designed to double the addressable patient population for post-transplant maintenance therapy.TScan

Article Sources:https://equity-insider.com/2025/10/03/the-small-biotech-thats-cracking-the-code-big-pharma-paid-billions-for/

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